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Human cells usually contain two sex chromosomes, one from the mother and one from the father. Usually, females have two X chromosomes XX and males have one X and one Y chromosome XY. The appearance of at least one Y chromosome with a properly functioning gene makes a male. Therefore, humans with XXYY are normally males. Males with XXYY syndrome have 48 chromosomes instead of the typical 46. This is why XXYY syndrome is sometimes written as 48, XXYY syndrome. It is estimated that XXYY affects one in every 18,000—40,000 male births. People normally have 46 chromosomes in each cell. Two of the 46 chromosomes, known as X and Y, are called sex chromosomes because they help determine whether a person will develop male or female sex characteristics. Females typically have two X chromosomes 46,XXand males have one X chromosome and one Y chromosome 46,XY. Extra copies of genes on the X chromosome interfere with male sexual development, preventing the testes from functioning normally and reducing the levels of testosterone. Many genes are found only on the X or Y chromosome, but genes in areas known as the pseudoautosomal regions are present on both sex chromosomes. Extra copies of genes from the pseudoautosomal regions of the extra X and Y chromosome contribute to the signs and symptoms of 48,XXYY syndrome; however, the specific genes have not been identified. Treatment consists of medications, behavioral therapies and intensive community support. Consultation with a developmental facebook double down casino problems, psychiatrist, or neurologist to develop a treatment plan including therapies, behavioral interventions, educational supports, and psychotropic medications for behavioral and psychiatric symptoms should be arranged. Good responses to standard medication treatments for inattention, impulsivity, anxiety, and mood instability are seen in this group and such treatment can positively impact academic progress, emotional wellbeing and long-term outcome. Poor fine motor coordination and the development of intention tremor can make handwriting slow and laborious, and occupational therapy and keyboarding should be introduced at an early age to facilitate schoolwork and self-help skills. Educational difficulties should be evaluated with a full psychological evaluation to identify discrepancies between verbal and performance skills and to identify individual academic needs. Expressive language skills are often affected throughout the lifespan and speech therapy interventions targeting expressive language skills, dyspraxia, and language pragmatics may be needed into adulthood. one facebook double down casino problems tills in adulthood. Additional treatment recommendations based on the individual strengths and weaknesses in XXYY syndrome may be required. An error in cell division called nondisjunction results in a reproductive cell with an abnormal number of chromosomes. In 48,XXYY syndrome, the extra sex chromosomes almost always come from a sperm cell. Nondisjunction may cause a sperm cell to gain two extra sex chromosomes, resulting in a sperm cell with three sex chromosomes one X and two Y chromosomes. If that sperm cell fertilizes facebook double down casino problems normal egg cell with one X chromosome, the resulting child will have two X chromosomes and two Y chromosomes in each of the body's cells. In a small percentage of cases, 48,XXYY syndrome results from nondisjunction of the sex chromosomes in a 46,XY embryo very soon after fertilization has occurred. This means that an normal sperm cell with one Y chromosome fertilized a normal egg cell with one X chromosome, but right after fertilization nondisjunction of the sex chromosomes caused the embryo to gain two extra sex chromosomes, resulting in a 48,XXYY embryo. Ockey inin 1960. It was described in a 15-year-old mentally challenged boy who showed signs of ; however, chromosome testing revealed 48, XXYY instead of the 47, XXY arrangement known to cause Kleinfelter syndrome. Because of this, 48, XXYY syndrome was originally considered a variation of Klinefelter syndrome. However, recent research shows some important differences in males with 48, XXYY compared to 47, XXY. Also, a larger percentage of males with XXYY have additional medical problems such as seizures, congenital elbow malformationsand tremor compared to males with XXY. XXYY is still considered a variation of Klinefelter syndrome by some definitions, mainly because the pathophysiology of the testicular dysfunction has not been shown to differ from 47, XXY, and the most current research does not suggest facebook double down casino problems there should be any differences in the evaluation and treatment of testosterone deficiency in 48, XXYY compared to 47, XXY. However, for the psychological and behavioral symptoms of XXYY syndrome, more extensive evaluations, interventions, and supports are usually needed compared to 47, Facebook double down casino problems due to more complex neurodevelopmental involvement. There is significant variability between individuals in the number and severity of the medical and neurodevelopmental problems associated with XXYY, and some individuals have mild symptoms while others are more significantly affected. Regents of the University of California, 2007. April 1, 2010, at the. Regents of the University of California, 2007. April 1, 2010, at the. Robbins and Cotran pathologic basis of disease. Louis, Mo: Elsevier Saunders. By using this site, you agree to the and. Wikipedia® is a registered trademark of thea non-profit organization.